June Newsletter

2021 No. 006
Dear Member/Student,
Welcome to the latest World Trichology Society newsletter. For WTS News, please go to the ‘Announcement’
page of the website: https://worldtrichologysociety.org/society/forums/forum/announcements/

Current Trichological and Health News

1. Similar Satisfaction With Virtual Appointments And In-Person Appointments For Hair Loss Healio reports researchers surveyed 40 patients who had an initial in-person or telemedicine visit for hair loss in March or April 2020 and found that “virtual telemedicine visits provided similar patient-reported satisfaction compared with in-person visits for hair disorders.” The findings were presented at AAD VMX 2021.
2. Is dutasteride an effective treatment for FFA? A retrospective observational study published in JAAD found oral dutasteride was the most effective therapy, depending on the dose, for the treatment of frontal fibrosing alopecia in real clinical practice compared to other systemic therapies or no systemic treatment. A total of 224 patients, all except two of which were women, with a follow-up between 12 to 108 months were included in the study. In the dutasteride group, the stabilization rate for the frontal, right, and left temporal regions after 12 months was 62%, 64%, and 62%; with other systemic therapies it was 60%, 35%, and 35%; and without systemic treatment it was 30%, 41%, and 38%. There was a statistically significant association of stabilization with an increasing dose of dutasteride — 88%, 91%, and 84% with a weekly treatment of five or seven doses of 0.5 mg.
3. Researchers Say Gene Linked To Balding May Increase COVID-19 Risks For Men HealthDay reported researchers found a gene linked to androgenetic alopecia may also help explain why COVID-19 has been more fatal for men on average than women. The condition “is caused by the activity of the androgen receptor (AR) gene, which in some men can lead to hair loss,” and “an enzyme called TMPRSS2, key to COVID-19 infection, is also androgensensitive, and might be affected by the AR gene as well.” The findings were presented at the virtual spring meeting of the European Academy of Dermatology and Venereology.
4. Telogen effluvium diagnosis during the COVID-19 pandemic In a recently published JAAD article in press, researchers found that the number of cases of telogen effluvium (TE) rose sharply during the COVID19 pandemic, although Hispanic and other non-white patients accounted for the majority of this increase. The authors compared the incidence of TE at eight New York City hospitals prior to and during the pandemic. During the first six months of the pandemic, there was a threefold increase in TE diagnoses compared to the preceding six months. Of the cases from the pandemic, 10 patients tested positive for COVID-19 and 98 were negative or untested. Additionally, nine of the 10 patients from the COVID cohort had underlying medical conditions that portent a more serious presentation of COVID-19, suggesting that the presence of comorbidities in conjunction with COVID-19 positivity may increase one’s risk of developing TE.
5. Low-Dose Oral Minoxidil Has Good Safety Profile As Treatment For Patients With Different Types Of Alopecia, Study Indicates Dermatology Advisor reports researchers found “low-dose oral minoxidil has a good safety profile as a treatment for patients with various types of alopecia, with a low frequency of systemic side effects.” The findings were published in the Journal of the American Academy of Dermatology.
6. Which herbal supplements may affect autoimmune skin diseases? A study published in JAAD reviews several in vivo and in vitro studies showing how immunostimulatory herbs such as Spirulina platensis, Aphanizomenon flos-aqua, Chlorella, Echinacea, and alfalfa upregulate cytokines and inflammatory pathways and can lead to precipitation or flare of autoimmune skin diseases, including cutaneous lupus erythematosus, dermatomyositis, and pemphigus. The authors conclude that with the increasing use of herbals supplements, patients with autoimmune skin diseases should be screened for supplement use and encouraged to comply with evidence-based treatments.
7. Potential FDA Approval Of More JAK Inhibitors Could Impact Treatment Of Patients With Different Skin Diseases In a feature article, Dermatology World reported on how the potential FDA approval of more JAK inhibitors could affect the treatment of patients with many different skin diseases. The FDA has already approved ruxolitinib and tofacitinib, but abrocitinib, baricitinib, and upadacitinib may be approved as soon as this year for the treatment of patients with alopecia areata, atopic dermatitis, psoriasis, and vitiligo.
8. Early Exposure To Antibiotics Tied To Higher Risk For Atopic Dermatitis, Study Indicates HealthDay reports researchers at the Karolinska Institutet found “exposure to antibiotics in utero and during the first year of life is associated with an increased risk for atopic dermatitis, with the correlation partially attenuated after adjustment for familial factors.” The findings were published in JAMA Network Open.
9. Women Urged To Take Care Of Health, WellBeing Via Preventive Care TODAY reports that “National Women’s Health Week, observed May 9-15, serves as a reminder for women and girls to take care of their health and well-being” The piece details “what women need to know about their preventive care.” For example, “Your dermatologist will determine how often you need a skin exam to detect cancer based on risk factors such as skin type, history of sun exposure and family history,” as “people with a history of melanoma should have a full-body exam by a dermatologist at least once a year, the American Academy of Dermatology noted.” Dr. Adam Friedman, professor and chair of dermatology at the George Washington School of Medicine and Health Sciences, said, “With May being Skin Cancer Awareness Month, there’s no better time to have a skin cancer screen than now if you have put it off for more than a year.”
10. More Than 90% Of Women Treated With Spironolactone For Acne May Demonstrate Complete Clearance At Long-Term Follow-Up, Study Indicates Healio reports, “More than 90% of women treated with spironolactone for acne demonstrated complete clearance at two years’ follow-up, according to a study” that sought “to describe short- and long-term outcomes in 403 adult women treated at a single academic medical center between 2008 and 2019.” The findings were published in the Journal of the American Academy of Dermatology.
11. Google Launches AI-Powered Dermatology Tool To Help People Understand Issues With Skin & Hair Health IT Analytics reports Google launched an AI-powered dermatology tool to help people “understand issues with their skin, hair, and nails.” The company “debuted the web-based application at its annual I/O developer conference on May 18.” The app “uses many of the same techniques that detect diabetic eye disease or lung cancer in CT scans to help consumers identify dermatologic issues using their phone’s camera.”
12. Long Working Hours Are Killing People Reuters reports, “Working long hours is killing hundreds of thousands of people a year in a worsening trend that may accelerate further due to the COVID-19 pandemic, the World Health Organization said on Monday.” A joint study between the WHO and the International Labour Organization,
    “showed that 745,000 people died from stroke and heart disease associated with long working hours in 2016.” That is almost a 30% increase since 2000. The data also show “people living in Southeast Asia and the Western Pacific region…were most affected.” This is “the first global study of the loss of life associated with longer working hours.” It “drew data from 194 countries” from 2000-2016. WHO’s Department of Environment, Climate Change and Health Director Maria Neira said, “Working 55 hours or more per week is a serious health hazard,” and “what we want to do with this information is promote more action, more protection of workers.”
13. Apremilast May Be Effective Therapy For Patients With Scalp Psoriasis, Study Indicates Dermatology Advisor reported researchers found in an extension of the phase 3 STYLE trial that “apremilast may be an effective therapy for” patients with “scalp psoriasis, including for [those] with scalp psoriasis that is poorly controlled by other treatments.” The findings were published in the British Journal of Dermatology.
    
    Journal Articles
    For journal publications, click on the URL under the title of the topic you wish to see and it will open to a free abstract of the article. For obtaining the full article, just follow the relevant prompts on the site (a payment may be required for the full article).
14. Prevention of chemically induced hair damage by means of treatment based on proteins and polysaccharides Flávio Bueno de Camargo Júnior, Marcos Magoiti Minami, et al. https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14148?
15. “Evaluation of efficacy of intradermal injection therapy Vs derma roller application for administration of QR678 Neo® hair regrowth formulation in the treatment of androgenetic alopecia‐ A Prospective Study” Debraj Shome, Rinky Kapoor, Sapna Vadera, Komal Doshi, Ghanshyam Patel, Temoor Mohammad Khan https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14139?
16. When hair loss is not just a cosmetic problem: Moth‐eaten alopecia in secondary syphilis. Mario Vaccaro MD, PhD, Laura Macca MD, Paolo Custurone MD, Fabrizio Guarneri MD, PhD https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14105?
17. “Comparison of QR 678® & QR678® Neo as monotherapy and as combination therapy with 5% Minoxidil solution and oral Finasteride in the treatment of male androgenetic alopecia—Which is better?” Debraj Shome MD, FRCS, FACS, FAACS, MBA, et al. https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14154?
18. “A preliminary result of adipose derived stem cell treatment for female pattern hair loss” Yusuf Kenan Coban https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14183?
19. Children with Trichotillomania in COVID‐19 outbreak Ümran Öner https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14200?
20. Reduction of telogen rate and increase of hair density in androgenetic alopecia by a cosmetic product: Results of a randomized, prospective, vehicle‐controlled double‐blind study in men Julia Welzel M.D, Helmut H. Wolff M.D, Wolfgang Gehring M.D https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.14158?
21. Is there a rationale for the use of botulinum toxin in the treatment of Androgenetic Alopecia? Daniel Fernandes Melo MSc, MD, Paulo Muller Ramos MD, MSc, PhD, Daniela Alves Pereira Antelo MD, MSc, PhD, Carla Jorge Machado PhD, Carlos Baptista Barcaui MD, MSc, PhD https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14177?
22. Classification of psychodermatological disorders Bárbara Roque Ferreira MD, Mohammad Jafferany MD https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14112?
23. Hair Transplantation Follicular Unit Excision (FUE): Introducing the Multipurpose Octagonal Ring Punch Roberto Trivellini, Aditya K Gupta https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14225?
24. Modified single‐hair follicular unit grafting to aesthetically restore eyelashes in Asians. Songjia Tang, Xiaoxin Wu, Peihua Liu, Jinsheng Li, Chunmao Han, Jufang Zhang https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.14234?
25. Extraordinary claims without extraordinary evidence: controversy on anti‐androgen therapy for COVID‐19 R.M. Trüeb, A. Régnier, N. Caballero‐Uribe, et al. https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.17249?
26. Pigtail hairs in syphilitic alopecia T.F. Gomes, F. Santiago, V. Guiote https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17255?
27. Male frontal fibrosing alopecia: study of 35 cases and association with sunscreens, facial skin and hair care products D.C. Westphal, N. Caballero‐Uribe, A. Regnier, et al. https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17317?
28. A Nationwide Multicenter Cross‐Sectional Questionnaire StudyOn The Use of Non‐dermatologic Facilities Among Patients With HairLoss Jee Woong Choi, Dong Chan Kim, Bark Lynn Lew, et al. https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17323?
29. Therapeutic management in paediatric alopecia areataA. Waśkiel-Burnat, M. Kołodziejak, M. Sikora, et al.https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17187?
30. Isolated autosomal recessive woolly hair/hypotrichosis: genetics,pathogenesis and therapiesMasashi Akiyamahttps://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17350?
31. Androgenetic alopecia in women and men is not related toCOVID‐19 infection severityShatila Torabi, Mahnaz Mozdourian, Roxana Rezazadeh, et al.https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17353?
32. Investigation of the Interactions of Cationic Guar with HumanHair by Electrokinetic AnalysisRoger L. McMullen, Donna Laura, Guojin Zhang, Bert Kroonhttps://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12704?
33. Role of Scalp Health in Achieving Optimal Hair Growth andRetentionAntonella Tosti, James Schwartzhttps://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12708?
34. Investigation of the molecular signature of greying hair shaftsRaoul Vyumvuhore, Laurie Verzeaux, Sophie Gilardeau, SylvieBordes, Elodie Aymard, Michel Manfait, Brigitte Closshttps://onlinelibrary.wiley.com/doi/abs/10.1111/ics.12700?
35. Investigation of the interactions of cationic guar with human hairby electrokinetic analysisRoger L. McMullen, Donna Laura, Guojin Zhang, Bert Kroonhttps://onlinelibrary.wiley.com/doi/full/10.1111/ics.12704?
36. Sensitization to benzyl salicylate and other allergens in patientswith frontal fibrosing alopeciaMaría A. Pastor‐Nieto, María E. Gatica‐Ortega, Consuelo Sánchez‐Herreros, Aránzazu Vergara‐Sánchez, Jaime Martínez‐Mariscal, Esther DeEusebio‐Murillohttps://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13763?
37. Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients Anna Di Landro, Luigi Naldi, Ella Glaser, Ralf Paus, Antonella Tosti https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14352?
38. Can antibiotic‐induced changes in the composition of the hair follicle microbiome regulate human hair growth? MB Lousada, J Edelkamp, T Lachnit, H Erdmann, R Paus https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14364?
39. Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients Anna Di Landro, Luigi Naldi, Ella Glaser, Ralf Paus, Antonella Tosti https://onlinelibrary.wiley.com/doi/full/10.1111/exd.14352?
40. Following historical ‘tracks’ of hair follicle miniaturisation in patterned hair loss: Are elastin bodies the forgotten aetiology? D. Hugh Rushton, Gillian E. Westgate, Dominique J. Van Neste https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14393?
41. Histopathological and immunohistochemical features of facial papules in frontal fibrosing alopecia A. Rakhshan, N. Momenpour, S. Dadkhahfar, M. Gheisari https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.14670?
42. Comorbidities of alopecia areata: a population‐based cohort study A. Egeberg, S. Anderson, E. Edson-Heredia, R. Burge https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.14507?
43. Association between Menopausal Hormone Therapy and Incidence of Psoriasis: A Secondary Analysis from the Women’s Health Initiative Randomized Clinical Trials A.A. Chan, J. Noguti, C.T. Y https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.20410?
44. Topical tofacitinib for the treatment of alopecia areata affecting facial hair K.L.S Kerkemeyer, R.D. Sinclair, B. Bhoyrul https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.20419?
45. Exploring the human hair follicle microbiome M.B. Lousada, T. Lachnit, J. Edelkamp, T. Rouillé, D. Ajdic, Y. Uchida, A. Di Nardo, T.C.G. Bosch, R. Paus https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.19461?
46. Host traits, lifestyle and environment are associated with human skin bacteria L. Moitinho-Silva, N. Boraczynski, H. Emmert, H. Baurecht, S. Szymczak, H. Schulz, D. Haller, J. Linseisen, C. Gieger, A. Peters, L. Tittmann, W. Lieb, C. Bang, A. Franke, E. Rodriguez, S. Weidinger https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.20072?
47. Alopecia barbae severity score: A novel scoring system to estimate the extent of beard loss and success of treatment A.J. Stefanis, P. Arenberger, M. Arenbergerova, S. Gkalpakiotis https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.20489?
48. Drug‐induced psoriasiform alopecia associated with interleukin‐ 17 inhibitor therapy Timothy L. Tan, Lauren Taglia, Pedram Yazdan https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13952?
49. African Oils in Dermatology Olusola Ayanlowo, Olufolakemi Cole–Adeife, Margaret Ilomuanya, Cynthia Ebie, Abigail Adegbulu, Obumneke Ezeanyache, Oghogho Odiase, Viola Ikebudu, Basirat Akanbi https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.14968?
50. Metabolic syndrome in patients with Alopecia Areata: a case‐ control study Fahimeh Abdollahimajd, Nasim Niknezhad, Negin Bahreini, Shima Younespour, Nastaran Namazi https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.14979?
51. The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables Nina G. Jablonski https://onlinelibrary.wiley.com/doi/full/10.1111/pcmr.12976?
52. TYK 2 inhibitors for the treatment of dermatologic conditions: the evolution of JAK inhibitors Christine E. Jo BSc, Melinda Gooderham MD, MSc, FRCPC, Jennifer Beecker MD, CCFP(EM), FRCPC, FAAD https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.15605?
53. A patch of nonscarring alopecia on the vertex of a 16‐year‐old male: a case report and a review of the literature Reine Merhy MD, Anne‐Sophie Sarkis MD, Lea El Khoury MD, Samer Ghosn MD, Farid Stephan MD https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.15616?
54. The role of prostaglandins in androgenetic alopecia Eleni Chovarda MD, Msc, Eleni Sotiriou MD, PhD, Elizabeth Lazaridou MD, PhD, Efstratios Vakirlis MD, PhD, Demetrios Ioannides MD, PhD https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.15378?
55. Nilotinib‐induced lichen planopilaris Ines Lahouel MD, Nesrine Ben Salah MD, Jacem Rouatbi MD, Sarra
    Boukhriss MD, Nouha Abdejlil MD, Monia Youssef PhD, Hichem Belhadjali PhD, Adnene Laatiri PhD, Jameledin Zili PhD https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.15647?
56. An Approach to Examining Tightly Coiled Hair Among Patients With Hair Loss in Race-Discordant Patient-Physician Interactions Ciara Grayson, MS; Candrice Heath, MD https://jamanetwork.com/journals/jamadermatology/fullarticle/2778022?
57. Low‐Level Light Therapy Downregulates Scalp InflammatoryBiomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil2% to Bring a Sustainable Hair Regrowth Activity
    Yann F. Mahe, Ahsène Cheniti, Charlotte Tacheau, Rosaria Antonelli, LienPlanard-Luong, Simon de Bernard, Laurent Buffat, Philippe Barbarat, Leila
    Kanoun-Copy https://onlinelibrary.wiley.com/doi/full/10.1002/lsm.23398?
58. Efficacy of Minoxidil Combined With Photobiomodulation for the Treatment of Male Androgenetic Alopecia. A Double‐Blind Half‐Head. Fernanda Ferrara MD, Priscila Kakizaki MD, Fernanda Freitas de Brito MD, Leticia Arsie Contin MD, Carla Jorge Machado PhD, Aline Donati MD https://onlinelibrary.wiley.com/doi/abs/10.1002/lsm.23411?

QUESTION FOR CTE® CREDIT (FOR FULL MEMBERS ONLY): PLEASE EMAIL ANSWER TO: BISSANWTS@EARTHLINK.NETIn Olusola Ayanlowo et al.’s research article regarding ” African Oils in
Dermatology”, name THREE constituents of the plant oils that may be beneficial for skin (scalp) care.

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